4uft: Difference between revisions
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<SX load='4uft' size='340' side='right' viewer='molstar' caption='[[4uft]], [[Resolution|resolution]] 4.30Å' scene=''> | <SX load='4uft' size='340' side='right' viewer='molstar' caption='[[4uft]], [[Resolution|resolution]] 4.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4uft]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4uft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_virus_strain_Halle Measles virus strain Halle] and [https://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UFT FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.3Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uft OCA], [https://pdbe.org/4uft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uft RCSB], [https://www.ebi.ac.uk/pdbsum/4uft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uft ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NCAP_MEASH NCAP_MEASH] Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</SX> | </SX> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Measles virus strain Halle]] | ||
[[Category: Spodoptera frugiperda]] | [[Category: Spodoptera frugiperda]] | ||
[[Category: Desfosses | [[Category: Desfosses A]] | ||
[[Category: Effantin | [[Category: Effantin G]] | ||
[[Category: Gutsche | [[Category: Gutsche I]] | ||
[[Category: Haupt | [[Category: Haupt M]] | ||
[[Category: Ling | [[Category: Ling WL]] | ||
[[Category: Ruigrok | [[Category: Ruigrok RWH]] | ||
[[Category: Sachse | [[Category: Sachse C]] | ||
[[Category: Schoehn | [[Category: Schoehn G]] | ||