4d6r: Difference between revisions
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==crystal structure of human JMJD2D in complex with N-OXALYLGLYCINE and bound o-toluenesulfonamide== | ==crystal structure of human JMJD2D in complex with N-OXALYLGLYCINE and bound o-toluenesulfonamide== | ||
<StructureSection load='4d6r' size='340' side='right' caption='[[4d6r]], [[Resolution|resolution]] 1.40Å' scene=''> | <StructureSection load='4d6r' size='340' side='right'caption='[[4d6r]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4d6r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6R OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4d6r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D6R FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IEJ:O-TOLUENESULFONAMIDE'>IEJ</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.398Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IEJ:O-TOLUENESULFONAMIDE'>IEJ</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6r OCA], [https://pdbe.org/4d6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d6r RCSB], [https://www.ebi.ac.uk/pdbsum/4d6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> | ||
==See Also== | |||
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Arrowsmith | [[Category: Homo sapiens]] | ||
[[Category: Bountra | [[Category: Large Structures]] | ||
[[Category: Bradley | [[Category: Arrowsmith CH]] | ||
[[Category: Burgess-Brown | [[Category: Bountra C]] | ||
[[Category: Crawley | [[Category: Bradley A]] | ||
[[Category: Burgess-Brown N]] | |||
[[Category: Edwards | [[Category: Crawley L]] | ||
[[Category: Gileadi | [[Category: Edwards A]] | ||
[[Category: Johansson | [[Category: Gileadi C]] | ||
[[Category: Krojer | [[Category: Johansson C]] | ||
[[Category: Oppermann | [[Category: Krojer T]] | ||
[[Category: Szykowska | [[Category: Oppermann U]] | ||
[[Category: Vollmar | [[Category: Szykowska A]] | ||
[[Category: | [[Category: Vollmar M]] | ||
[[Category: Von Delft F]] | |||