4d50: Difference between revisions

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==Structure of human deoxyhypusine hydroxylase==
==Structure of human deoxyhypusine hydroxylase==
<StructureSection load='4d50' size='340' side='right' caption='[[4d50]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4d50' size='340' side='right'caption='[[4d50]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4d50]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D50 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4d50]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D50 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GAI:GUANIDINE'>GAI</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d4z|4d4z]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GAI:GUANIDINE'>GAI</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxyhypusine_monooxygenase Deoxyhypusine monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.29 1.14.99.29] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d50 OCA], [https://pdbe.org/4d50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d50 RCSB], [https://www.ebi.ac.uk/pdbsum/4d50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d50 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d50 OCA], [http://pdbe.org/4d50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d50 RCSB], [http://www.ebi.ac.uk/pdbsum/4d50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d50 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DOHH_HUMAN DOHH_HUMAN]] Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.[HAMAP-Rule:MF_03101]<ref>PMID:16371467</ref> <ref>PMID:19706422</ref>
[https://www.uniprot.org/uniprot/DOHH_HUMAN DOHH_HUMAN] Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.[HAMAP-Rule:MF_03101]<ref>PMID:16371467</ref> <ref>PMID:19706422</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Deoxyhypusine monooxygenase]]
[[Category: Homo sapiens]]
[[Category: Han, Z]]
[[Category: Large Structures]]
[[Category: Hilgenfeld, R]]
[[Category: Han Z]]
[[Category: Sakai, N]]
[[Category: Hilgenfeld R]]
[[Category: Oxidoreductase]]
[[Category: Sakai N]]

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