4cx5: Difference between revisions

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 ==Structure of rat neuronal nitric oxide synthase H341L mutant heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL) PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE==
-<StructureSection load='4cx5' size='340' side='right' caption='[[4cx5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='4cx5' size='340' side='right'caption='[[4cx5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4cx5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CX5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4cx5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CX5 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HW8:4-METHYL-6-{[(3R,4R)-4-{[5-(PYRIDIN-2-YL)PENTYL]OXY}PYRROLIDIN-3-YL]METHYL}PYRIDIN-2-AMINE'>HW8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cwv|4cwv]], [[4cww|4cww]], [[4cwx|4cwx]], [[4cwy|4cwy]], [[4cwz|4cwz]], [[4cx0|4cx0]], [[4cx1|4cx1]], [[4cx2|4cx2]], [[4cx3|4cx3]], [[4cx4|4cx4]], [[4cx6|4cx6]], [[4cx7|4cx7]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HW8:4-METHYL-6-{[(3R,4R)-4-{[5-(PYRIDIN-2-YL)PENTYL]OXY}PYRROLIDIN-3-YL]METHYL}PYRIDIN-2-AMINE'>HW8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cx5 OCA], [https://pdbe.org/4cx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cx5 RCSB], [https://www.ebi.ac.uk/pdbsum/4cx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cx5 ProSAT]</span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cx5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cx5 RCSB], [http://www.ebi.ac.uk/pdbsum/4cx5 PDBsum]</span></td></tr>
+</table>
-<table>
+== Function ==
+[https://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4cx5" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Li, H.]]
+[[Category: Large Structures]]
-[[Category: Poulos, T L.]]
+[[Category: Rattus norvegicus]]
-[[Category: Inhibitor complex]]
+[[Category: Li H]]
-[[Category: Oxidoreductase]]
+[[Category: Poulos TL]]