4cwt: Difference between revisions

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 ==Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor==
-<StructureSection load='4cwt' size='340' side='right' caption='[[4cwt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+<StructureSection load='4cwt' size='340' side='right'caption='[[4cwt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4cwt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWT FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4cwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CWT FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IK9:2-{[(2Z)-5-(1,3-BENZODIOXOL-5-YLMETHYL)-8-FLUORO-2-IMINO-2,3-DIHYDRO[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-10-YL]AMINO}ETHANOL'>IK9</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cwf|4cwf]], [[4cwn|4cwn]], [[4cwo|4cwo]], [[4cwp|4cwp]], [[4cwq|4cwq]], [[4cwr|4cwr]], [[4cws|4cws]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IK9:2-{[(2Z)-5-(1,3-BENZODIOXOL-5-YLMETHYL)-8-FLUORO-2-IMINO-2,3-DIHYDRO[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-10-YL]AMINO}ETHANOL'>IK9</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwt OCA], [http://pdbe.org/4cwt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cwt RCSB], [http://www.ebi.ac.uk/pdbsum/4cwt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwt ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwt OCA], [https://pdbe.org/4cwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cwt RCSB], [https://www.ebi.ac.uk/pdbsum/4cwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwt ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
+[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 19: @@
 </div>
 <div class="pdbe-citations 4cwt" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Amboldi, N]]
+[[Category: Homo sapiens]]
-[[Category: Brasca, G]]
+[[Category: Large Structures]]
-[[Category: Caronni, D]]
+[[Category: Amboldi N]]
-[[Category: Casale, E]]
+[[Category: Brasca G]]
-[[Category: Casuscelli, F]]
+[[Category: Caronni D]]
-[[Category: Colombo, N]]
+[[Category: Casale E]]
-[[Category: Dalvit, C]]
+[[Category: Casuscelli F]]
-[[Category: Felder, E R]]
+[[Category: Colombo N]]
-[[Category: Fogliatto, G]]
+[[Category: Dalvit C]]
-[[Category: Isacchi, A]]
+[[Category: Felder ER]]
-[[Category: Mantegani, S]]
+[[Category: Fogliatto G]]
-[[Category: Polucci, P]]
+[[Category: Isacchi A]]
-[[Category: Riceputi, L]]
+[[Category: Mantegani S]]
-[[Category: Sola, F]]
+[[Category: Polucci P]]
-[[Category: Visco, C]]
+[[Category: Riceputi L]]
-[[Category: Zuccotto, F]]
+[[Category: Sola F]]
-[[Category: Chaperone]]
+[[Category: Visco C]]
+[[Category: Zuccotto F]]