4cgm: Difference between revisions

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==Leishmania major N-myristoyltransferase in complex with a biphenyl- derivative inhibitor==
==Leishmania major N-myristoyltransferase in complex with a biphenyl- derivative inhibitor==
<StructureSection load='4cgm' size='340' side='right' caption='[[4cgm]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4cgm' size='340' side='right'caption='[[4cgm]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cgm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CGM FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cgm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CGM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CWZ:N-[[3-[3-(6,7-DIHYDRO-4H-[1,3]THIAZOLO[5,4-C]PYRIDIN-5-YLMETHYL)PHENYL]PHENYL]METHYL]-2-PYRIDIN-3-YL-ETHANAMINE'>CWZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cgl|4cgl]], [[4cgn|4cgn]], [[4cgo|4cgo]], [[4cgp|4cgp]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CWZ:N-[[3-[3-(6,7-DIHYDRO-4H-[1,3]THIAZOLO[5,4-C]PYRIDIN-5-YLMETHYL)PHENYL]PHENYL]METHYL]-2-PYRIDIN-3-YL-ETHANAMINE'>CWZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cgm OCA], [https://pdbe.org/4cgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cgm RCSB], [https://www.ebi.ac.uk/pdbsum/4cgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cgm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cgm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cgm RCSB], [http://www.ebi.ac.uk/pdbsum/4cgm PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).  
[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4cgm" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glycylpeptide N-tetradecanoyltransferase]]
[[Category: Large Structures]]
[[Category: Bell, A S]]
[[Category: Leishmania major]]
[[Category: Brannigan, J A]]
[[Category: Bell AS]]
[[Category: Hutton, J A]]
[[Category: Brannigan JA]]
[[Category: Leatherbarrow, R J]]
[[Category: Hutton JA]]
[[Category: Roberts, S M]]
[[Category: Leatherbarrow RJ]]
[[Category: Smith, D F]]
[[Category: Roberts SM]]
[[Category: Tate, E W]]
[[Category: Smith DF]]
[[Category: Wilkinson, A J]]
[[Category: Tate EW]]
[[Category: Myristoylation]]
[[Category: Wilkinson AJ]]
[[Category: Transferase]]

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