4cdo: Difference between revisions
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==Crystal structure of PQBP1 bound to spliceosomal U5-15kD== | ==Crystal structure of PQBP1 bound to spliceosomal U5-15kD== | ||
<StructureSection load='4cdo' size='340' side='right' caption='[[4cdo]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4cdo' size='340' side='right'caption='[[4cdo]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cdo]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4cdo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CDO FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cdo OCA], [https://pdbe.org/4cdo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cdo RCSB], [https://www.ebi.ac.uk/pdbsum/4cdo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cdo ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/PQBP1_HUMAN PQBP1_HUMAN] X-linked intellectual deficit, Sutherland-Haan type;X-linked intellectual deficit, Golabi-Ito-Hall type;X-linked intellectual deficit, Porteous type;Hamel cerebro-palato-cardiac syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | == Function == | ||
[[ | [https://www.uniprot.org/uniprot/PQBP1_HUMAN PQBP1_HUMAN] May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.<ref>PMID:10332029</ref> <ref>PMID:10198427</ref> <ref>PMID:12062018</ref> [https://www.uniprot.org/uniprot/TXN4A_HUMAN TXN4A_HUMAN] Essential role in pre-mRNA splicing. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4cdo" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4cdo" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[U5-15kD|U5-15kD]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Kojima | [[Category: Large Structures]] | ||
[[Category: Mizuguchi | [[Category: Kojima R]] | ||
[[Category: Nabeshima | [[Category: Mizuguchi M]] | ||
[[Category: Obita | [[Category: Nabeshima Y]] | ||
[[Category: Okazawa | [[Category: Obita T]] | ||
[[Category: Serita | [[Category: Okazawa H]] | ||
[[Category: Serita T]] | |||