4c3e: Difference between revisions

<StructureSection load='4c3e' size='340' side='right'caption='[[4c3e]], [[Resolution|resolution]] 2.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[4c3e]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_A2 Human respiratory syncytial virus A2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C3E FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c3e OCA], [https://pdbe.org/4c3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c3e RCSB], [https://www.ebi.ac.uk/pdbsum/4c3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c3e ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/M21_HRSVA M21_HRSVA] Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of RSV mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate NF-kappa-B through association with host RELA.<ref>PMID:8552680</ref> <ref>PMID:9420254</ref> <ref>PMID:10364337</ref>  

[[Category: Human respiratory syncytial virus A2]]

[[Category: Large Structures]]

[[Category: Ariza A]]

[[Category: Barr JN]]

[[Category: Carroll MW]]

[[Category: Edwards TA]]

[[Category: Eleouet JF]]

[[Category: Hiscox JA]]

[[Category: Richard CA]]

[[Category: Silman NJ]]

[[Category: Tanner SJ]]

[[Category: Trincao J]]

[[Category: Wu W]]