4bs9: Difference between revisions
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The | ==Structure of the heterocyclase TruD== | ||
<StructureSection load='4bs9' size='340' side='right'caption='[[4bs9]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4bs9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Uncultured_Prochloron_sp._06037A Uncultured Prochloron sp. 06037A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BS9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bs9 OCA], [https://pdbe.org/4bs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bs9 RCSB], [https://www.ebi.ac.uk/pdbsum/4bs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bs9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/B2KYG8_9PROC B2KYG8_9PROC] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Counting backwards: The cyanobactin class of heterocyclases, exemplified by TruD, possess an almost unique combination of processivity, specificity, chemical versatility, and promiscuity. TruD is shown by biochemical assay to be an adenylase, and processes cysteines in a defined order. The entire substrate leader can be removed and TruD will process a single specific cysteine residue; however the role of leader is to permit processivity through a balance of recognition. ATP/AMP=adenosine tri/monophosphate; PPi=pyrophosphate. | |||
The Cyanobactin Heterocyclase Enzyme: A Processive Adenylase That Operates with a Defined Order of Reaction.,Koehnke J, Bent AF, Zollman D, Smith K, Houssen WE, Zhu X, Mann G, Lebl T, Scharff R, Shirran S, Botting CH, Jaspars M, Schwarz-Linek U, Naismith JH Angew Chem Int Ed Engl. 2013 Nov 8. doi: 10.1002/anie.201306302. PMID:24214017<ref>PMID:24214017</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4bs9" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Uncultured Prochloron sp. 06037A]] | |||
[[Category: Bent AF]] | |||
[[Category: Botting CH]] | |||
[[Category: Houssen WE]] | |||
[[Category: Jaspars M]] | |||
[[Category: Koehnke J]] | |||
[[Category: Lebl T]] | |||
[[Category: Mann G]] | |||
[[Category: Naismith JH]] | |||
[[Category: Scharff R]] | |||
[[Category: Schwarz-Linek U]] | |||
[[Category: Shirran S]] | |||
[[Category: Smith K]] | |||
[[Category: Zhu X]] | |||
[[Category: Zollman D]] | |||
Latest revision as of 14:04, 9 May 2024
Structure of the heterocyclase TruDStructure of the heterocyclase TruD
Structural highlights
FunctionPublication Abstract from PubMedCounting backwards: The cyanobactin class of heterocyclases, exemplified by TruD, possess an almost unique combination of processivity, specificity, chemical versatility, and promiscuity. TruD is shown by biochemical assay to be an adenylase, and processes cysteines in a defined order. The entire substrate leader can be removed and TruD will process a single specific cysteine residue; however the role of leader is to permit processivity through a balance of recognition. ATP/AMP=adenosine tri/monophosphate; PPi=pyrophosphate. The Cyanobactin Heterocyclase Enzyme: A Processive Adenylase That Operates with a Defined Order of Reaction.,Koehnke J, Bent AF, Zollman D, Smith K, Houssen WE, Zhu X, Mann G, Lebl T, Scharff R, Shirran S, Botting CH, Jaspars M, Schwarz-Linek U, Naismith JH Angew Chem Int Ed Engl. 2013 Nov 8. doi: 10.1002/anie.201306302. PMID:24214017[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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