4bp7: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-<div  style="background-color:yellow;" border="1" cellpadding="5">''Warning: this is a large structure, and loading might take a long time or not happen at all.''</div>
+==Asymmetric structure of a virus-receptor complex==
-== Asymmetric structure of a virus-receptor complex ==
+<SX load='4bp7' size='340' side='right' viewer='molstar' caption='[[4bp7]], [[Resolution|resolution]] 39.00&Aring;' scene=''>
-[[Image:4bp7.jpg]]
+== Structural highlights ==
-[[Category: Hiscox, J.A]]
+<table><tr><td colspan='2'>[[4bp7]] is a 180 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_MS2 Escherichia virus MS2]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bp4 4bp4], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bp5 4bp5] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bp6 4bp6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BP7 FirstGlance]. <br>
-[[Category: Dent, K.C]]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 39&#8491;</td></tr>
-[[Category: Barker, A.M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bp7 OCA], [https://pdbe.org/4bp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bp7 RCSB], [https://www.ebi.ac.uk/pdbsum/4bp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bp7 ProSAT]</span></td></tr>
-[[Category: Ranson, N.A]]
+</table>
-[[Category: Barr, J.N]]
+== Function ==
-[[Category: Stockley, P.G]]
+[https://www.uniprot.org/uniprot/CAPSD_BPMS2 CAPSD_BPMS2] Self-assembles to form the T=3 icosahedral virus shell that protects the viral nucleic acid. Acts as a translational repressor by binding with high specificity to a single stem-loop structure in the genomic RNA that contains the initiation codon of the gene for the viral replicase. Involved in virus assembly through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome.<ref>PMID:16531233</ref> <ref>PMID:18662904</ref> <ref>PMID:26608810</ref> <ref>PMID:8254664</ref> <ref>PMID:9245600</ref> <ref>PMID:9469847</ref>
-[[Category: Thompson, R]]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Simple, spherical RNA viruses have well-understood, symmetric protein capsids, but little structural information is available for their asymmetric components, such as minor proteins and their genomes, which are vital for infection. Here, we report an asymmetric structure of bacteriophage MS2, attached to its receptor, the F-pilus. Cryo-electron tomography and subtomographic averaging of such complexes result in a structure containing clear density for the packaged genome, implying that the conformation of the genome is the same in each virus particle. The data also suggest that the single-copy viral maturation protein breaks the symmetry of the capsid, occupying a position that would be filled by a coat protein dimer in an icosahedral shell. This capsomere can thus fulfill its known biological roles in receptor and genome binding and suggests an exit route for the genome during infection.
+The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release.,Dent KC, Thompson R, Barker AM, Hiscox JA, Barr JN, Stockley PG, Ranson NA Structure. 2013 Jun 25. pii: S0969-2126(13)00194-9. doi:, 10.1016/j.str.2013.05.012. PMID:23810697<ref>PMID:23810697</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4bp7" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
+== References ==
+<references/>
+__TOC__
+</SX>
+[[Category: Escherichia virus MS2]]
+[[Category: Large Structures]]
+[[Category: Barker AM]]
+[[Category: Barr JN]]
+[[Category: Dent KC]]
+[[Category: Hiscox JA]]
+[[Category: Ranson NA]]
+[[Category: Stockley PG]]
+[[Category: Thompson R]]