4b93: Difference between revisions
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==Complex of Vamp7 cytoplasmic domain with 2nd ankyrin repeat domain of Varp== | ==Complex of Vamp7 cytoplasmic domain with 2nd ankyrin repeat domain of Varp== | ||
<StructureSection load='4b93' size='340' side='right' caption='[[4b93]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4b93' size='340' side='right'caption='[[4b93]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4b93]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4b93]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B93 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b93 OCA], [https://pdbe.org/4b93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b93 RCSB], [https://www.ebi.ac.uk/pdbsum/4b93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b93 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/VAMP7_MOUSE VAMP7_MOUSE] Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.<ref>PMID:15470500</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4b93" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Ankyrin repeat domain-containing protein 3D structures|Ankyrin repeat domain-containing protein 3D structures]] | |||
*[[Vesicle-associated membrane protein 3D structures|Vesicle-associated membrane protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Evans | [[Category: Evans PR]] | ||
[[Category: Luzio | [[Category: Luzio JP]] | ||
[[Category: Owen | [[Category: Owen DJ]] | ||
[[Category: Schaefer | [[Category: Schaefer IB]] | ||