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==Identification and structural characterization of PDE10 fragment inhibitors== | |||
<StructureSection load='4ajd' size='340' side='right'caption='[[4ajd]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ajd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AJD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F04:2-ETHYL-4-METHYL-PHTHALAZIN-1-ONE'>F04</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ajd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajd OCA], [https://pdbe.org/4ajd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ajd RCSB], [https://www.ebi.ac.uk/pdbsum/4ajd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
==See Also== | |||
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Aharony D]] | |||
[[Category: Akerud T]] | |||
[[Category: Albert JS]] | |||
[[Category: Back E]] | |||
[[Category: Geschwindner S]] | |||
[[Category: Hillertz P]] | |||
[[Category: Horsefeld R]] | |||
[[Category: Johansson P]] | |||
[[Category: Scott C]] | |||
[[Category: Spadola L]] | |||
[[Category: Spear N]] | |||
[[Category: Tian G]] | |||
[[Category: Tigerstrom A]] | |||
Latest revision as of 13:50, 9 May 2024
Identification and structural characterization of PDE10 fragment inhibitorsIdentification and structural characterization of PDE10 fragment inhibitors
Structural highlights
FunctionPDE10_HUMAN Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1] See AlsoReferences |
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