4aap: Difference between revisions

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 ==Crystal structure of JMJD5 domain of human Lysine-specific demethylase 8 (KDM8) in complex with N-oxalylglycine (NOG)==
-<StructureSection load='4aap' size='340' side='right' caption='[[4aap]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='4aap' size='340' side='right'caption='[[4aap]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4aap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AAP FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4aap]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AAP FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aap RCSB], [http://www.ebi.ac.uk/pdbsum/4aap PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aap OCA], [https://pdbe.org/4aap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aap RCSB], [https://www.ebi.ac.uk/pdbsum/4aap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aap ProSAT]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
+==See Also==
+*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
 __TOC__
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Allerston, C.]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Allerston C]]
-[[Category: Bountra, C.]]
+[[Category: Arrowsmith CH]]
-[[Category: Canning, P.]]
+[[Category: Bountra C]]
-[[Category: Delft, F Von.]]
+[[Category: Canning P]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Gadhave, A.]]
+[[Category: Gadhave A]]
-[[Category: Johansson, C.]]
+[[Category: Johansson C]]
-[[Category: Krojer, T.]]
+[[Category: Krojer T]]
-[[Category: Oppermann, U.]]
+[[Category: Oppermann U]]
-[[Category: Vollmar, M.]]
+[[Category: Vollmar M]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Oxidoreductase]]
+[[Category: Von Delft F]]