4a9e: Difference between revisions

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 ==N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 3-methyl-1,2,3,4- tetrahydroquinazolin-2-one==
-<StructureSection load='4a9e' size='340' side='right' caption='[[4a9e]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
+<StructureSection load='4a9e' size='340' side='right'caption='[[4a9e]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4a9e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A9E FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4a9e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A9E FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PF:3-METHYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>3PF</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yek|2yek]], [[1x0j|1x0j]], [[2ydw|2ydw]], [[4a9k|4a9k]], [[4a9m|4a9m]], [[4a9h|4a9h]], [[4a9o|4a9o]], [[4a9f|4a9f]], [[4a9l|4a9l]], [[4a9n|4a9n]], [[4a9j|4a9j]], [[4a9p|4a9p]], [[4a9i|4a9i]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PF:3-METHYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>3PF</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a9e RCSB], [http://www.ebi.ac.uk/pdbsum/4a9e PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9e OCA], [https://pdbe.org/4a9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a9e RCSB], [https://www.ebi.ac.uk/pdbsum/4a9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a9e ProSAT]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery.,Chung CW, Dean TW, Woolven JM, Bamborough P J Med Chem. 2011 Dec 5. PMID:22136404<ref>PMID:22136404</ref>
-From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4a9e" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
 == References ==
 <references/>
@@ Line 20: / Line 27: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Bamborough, P.]]
+[[Category: Large Structures]]
-[[Category: Chung, C.]]
+[[Category: Bamborough P]]
-[[Category: Epigenetic reader]]
+[[Category: Chung C]]
-[[Category: Histone]]
-[[Category: Inhibitor]]
-[[Category: Signaling protein]]