4a8d: Difference between revisions

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<table><tr><td colspan='2'>[[4a8d]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A8D FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 28&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a8d OCA], [https://pdbe.org/4a8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a8d RCSB], [https://www.ebi.ac.uk/pdbsum/4a8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a8d ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/DEGP_ECOLI DEGP_ECOLI] DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP).<ref>PMID:2180903</ref> <ref>PMID:8830688</ref> <ref>PMID:10319814</ref> <ref>PMID:18505836</ref> <ref>PMID:12730160</ref> <ref>PMID:18496527</ref>  

*[[Porin 3D structures|Porin 3D structures]]

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[[Category: Large Structures]]

[[Category: Clausen T]]

[[Category: Ehrmann M]]

[[Category: Krojer T]]

[[Category: Malet H]]

[[Category: Saibil HR]]

[[Category: Sawa J]]

[[Category: Schafer E]]