4a5u: Difference between revisions

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 ==Turnip yellow mosaic virus proteinase and Escherichia coli 30S ribosomal S15==
-<StructureSection load='4a5u' size='340' side='right' caption='[[4a5u]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='4a5u' size='340' side='right'caption='[[4a5u]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4a5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Tymv Tymv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A5U FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4a5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)] and [https://en.wikipedia.org/wiki/Turnip_yellow_mosaic_virus Turnip yellow mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A5U FirstGlance]. <br>
-</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a5u OCA], [http://pdbe.org/4a5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a5u RCSB], [http://www.ebi.ac.uk/pdbsum/4a5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a5u ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a5u OCA], [https://pdbe.org/4a5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a5u RCSB], [https://www.ebi.ac.uk/pdbsum/4a5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a5u ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/POLR_TYMV POLR_TYMV]] Acts as a cysteine protease, methyltransferase and deubiquitinase. The cyteine protease activity cleaves the polyprotein giving rise to mature proteins. The methyltransferase domain is probably involved in viral RNA capping. The deubiquitylating activity counteracts the degradation of the viral polymerase mediated by the host ubiquitin-proteasome system. The polymerase is thus stabilized and infectivity is increased.<ref>PMID:22117220</ref>   RNA-directed RNA polymerase is responsible for the replication and transcription of the genome.<ref>PMID:22117220</ref>  [[http://www.uniprot.org/uniprot/E8Y371_ECOKO E8Y371_ECOKO]] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity).[HAMAP-Rule:MF_01343]  One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA (By similarity).[HAMAP-Rule:MF_01343]
+[https://www.uniprot.org/uniprot/POLR_TYMV POLR_TYMV] Acts as a cysteine protease, methyltransferase and deubiquitinase. The cyteine protease activity cleaves the polyprotein giving rise to mature proteins. The methyltransferase domain is probably involved in viral RNA capping. The deubiquitylating activity counteracts the degradation of the viral polymerase mediated by the host ubiquitin-proteasome system. The polymerase is thus stabilized and infectivity is increased.<ref>PMID:22117220</ref>   RNA-directed RNA polymerase is responsible for the replication and transcription of the genome.<ref>PMID:22117220</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 25: / Line 25: @@
 __TOC__
 </StructureSection>
-[[Category: Escherichia coli]]
+[[Category: Large Structures]]
-[[Category: RNA-directed RNA polymerase]]
+[[Category: Turnip yellow mosaic virus]]
-[[Category: Tymv]]
+[[Category: Beaurepaire L]]
-[[Category: Beaurepaire, L]]
+[[Category: Bressanelli S]]
-[[Category: Bressanelli, S]]
+[[Category: Robin C]]
-[[Category: Robin, C]]
-[[Category: Cysteine proteinase]]
-[[Category: Transferase-rna binding protein complex]]