4a22: Difference between revisions

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-==STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE BOUND TO N-(4-HYDROXYBUTYL)-GLYCOLOHYDROXAMIC ACID BIS-PHOSPHATE==
-<StructureSection load='4a22' size='340' side='right' caption='[[4a22]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+==Structure of Mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase bound to N-(4-hydroxybutyl)- glycolohydroxamic acid bis- phosphate==
+<StructureSection load='4a22' size='340' side='right'caption='[[4a22]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4a22]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A22 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4a22]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A22 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TD4:4-{HYDROXY[(PHOSPHONOOXY)ACETYL]AMINO}BUTYL+DIHYDROGEN+PHOSPHATE'>TD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a21|4a21]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TD4:4-{HYDROXY[(PHOSPHONOOXY)ACETYL]AMINO}BUTYL+DIHYDROGEN+PHOSPHATE'>TD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a22 OCA], [https://pdbe.org/4a22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a22 RCSB], [https://www.ebi.ac.uk/pdbsum/4a22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a22 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a22 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a22 RCSB], [http://www.ebi.ac.uk/pdbsum/4a22 PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/ALF_MYCTU ALF_MYCTU] Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 16: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4a22" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Aldolase|Aldolase]]
+*[[Aldolase 3D structures|Aldolase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Fructose-bisphosphate aldolase]]
+[[Category: Large Structures]]
 [[Category: Mycobacterium tuberculosis]]
-[[Category: Coincon, M]]
+[[Category: Coincon M]]
-[[Category: Daher, R]]
+[[Category: Daher R]]
-[[Category: Ehrt, S]]
+[[Category: De la Paz Santangelo M]]
-[[Category: Gest, P M]]
+[[Category: Ehrt S]]
-[[Category: Gonzalez-Juarrero, M]]
+[[Category: Gest PM]]
-[[Category: Guerin, M E]]
+[[Category: Gonzalez-Juarrero M]]
-[[Category: Jackson, M]]
+[[Category: Guerin ME]]
-[[Category: Lenaerts, A J]]
+[[Category: Jackson M]]
-[[Category: Pham, H]]
+[[Category: Lenaerts AJ]]
-[[Category: Puckett, S E]]
+[[Category: Pham H]]
-[[Category: Ryan, G]]
+[[Category: Puckett SE]]
-[[Category: Santangelo, M De La Paz]]
+[[Category: Ryan G]]
-[[Category: Schnappinger, D]]
+[[Category: Schnappinger D]]
-[[Category: Spencer, J S]]
+[[Category: Spencer JS]]
-[[Category: Sygusch, J]]
+[[Category: Sygusch J]]
-[[Category: Therisod, M]]
+[[Category: Therisod M]]
-[[Category: Lyase]]
-[[Category: Lyase-inhibitor complex]]