3znv: Difference between revisions
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==Crystal structure of the OTU domain of OTULIN at 1.3 Angstroms.== | ==Crystal structure of the OTU domain of OTULIN at 1.3 Angstroms.== | ||
<StructureSection load='3znv' size='340' side='right' caption='[[3znv]], [[Resolution|resolution]] 1.30Å' scene=''> | <StructureSection load='3znv' size='340' side='right'caption='[[3znv]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3znv]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3znv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZNV FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3znv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znv OCA], [https://pdbe.org/3znv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3znv RCSB], [https://www.ebi.ac.uk/pdbsum/3znv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3znv ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/OTUL_HUMAN OTUL_HUMAN] Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.<ref>PMID:23827681</ref> <ref>PMID:23806334</ref> <ref>PMID:23746843</ref> <ref>PMID:23708998</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Elliott | [[Category: Elliott PR]] | ||
[[Category: Glockner | [[Category: Glockner L]] | ||
[[Category: Hofmann | [[Category: Hofmann K]] | ||
[[Category: Keusekotten | [[Category: Keusekotten K]] | ||
[[Category: Komander | [[Category: Komander D]] | ||
[[Category: Krappmann | [[Category: Krappmann D]] | ||
[[Category: Kulathu | [[Category: Kulathu Y]] | ||
[[Category: Wauer | [[Category: Wauer T]] | ||