2xdl: Difference between revisions
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== | |||
<StructureSection load='2xdl' size='340' side='right' caption='[[2xdl]], [[Resolution|resolution]] 1.98Å' scene=''> | ==Structure of HSP90 with small molecule inhibitor bound== | ||
<StructureSection load='2xdl' size='340' side='right'caption='[[2xdl]], [[Resolution|resolution]] 1.98Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xdl]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2xdl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XDL FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> | ||
<tr><td class="sblockLbl"><b>[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DL:2-METHYL-4-DIETHYLAMIDE-PHENOL'>2DL</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdl OCA], [https://pdbe.org/2xdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xdl RCSB], [https://www.ebi.ac.uk/pdbsum/2xdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xdl ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xdl_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xdl_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xdl ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2xdl" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Heat Shock | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Callaghan | [[Category: Large Structures]] | ||
[[Category: Carr | [[Category: Callaghan O]] | ||
[[Category: Chessari | [[Category: Carr MG]] | ||
[[Category: Congreve | [[Category: Chessari G]] | ||
[[Category: Cowan | [[Category: Congreve M]] | ||
[[Category: Coyle | [[Category: Cowan S]] | ||
[[Category: Downham | [[Category: Coyle JE]] | ||
[[Category: Figueroa | [[Category: Downham R]] | ||
[[Category: Frederickson | [[Category: Figueroa E]] | ||
[[Category: Graham | [[Category: Frederickson M]] | ||
[[Category: | [[Category: Graham B]] | ||
[[Category: Murray | [[Category: McMenamin R]] | ||
[[Category: | [[Category: Murray CW]] | ||
[[Category: Patel | [[Category: OBrien MA]] | ||
[[Category: Phillips | [[Category: Patel S]] | ||
[[Category: Williams | [[Category: Phillips TR]] | ||
[[Category: Woodhead | [[Category: Williams G]] | ||
[[Category: Woolford | [[Category: Woodhead AJ]] | ||
[[Category: Woolford AJA]] | |||