2xd8: Difference between revisions
New page: '''Unreleased structure''' The entry 2xd8 is ON HOLD until sometime in the future Authors: Liu, X., Zhang, Q., Murata, K., Baker, M.L., Sullivan, M.B., Fu, C., Dougherty, M., Schmid, M.... |
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==Capsid structure of the infectious Prochlorococcus Cyanophage P-SSP7== | |||
<SX load='2xd8' size='340' side='right' viewer='molstar' caption='[[2xd8]], [[Resolution|resolution]] 4.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2xd8]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Prochlorococcus_virus_PSSP7 Prochlorococcus virus PSSP7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XD8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.6Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xd8 OCA], [https://pdbe.org/2xd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xd8 RCSB], [https://www.ebi.ac.uk/pdbsum/2xd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xd8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q58N30_BPPRP Q58N30_BPPRP] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xd8_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xd8 ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Podovirus P-SSP7 infects Prochlorococcus marinus, the most abundant oceanic photosynthetic microorganism. Single-particle cryo-electron microscopy yields icosahedral and asymmetrical structures of infectious P-SSP7 with 4.6-A and 9-A resolution, respectively. The asymmetric reconstruction reveals how symmetry mismatches are accommodated among five of the gene products at the portal vertex. Reconstructions of infectious and empty particles show a conformational change of the 'valve' density in the nozzle, an orientation difference in the tail fibers, a disordering of the C terminus of the portal protein and the disappearance of the core proteins. In addition, cryo-electron tomography of P-SSP7 infecting Prochlorococcus showed the same tail-fiber conformation as that in empty particles. Our observations suggest a mechanism whereby, upon binding to the host cell, the tail fibers induce a cascade of structural alterations of the portal vertex complex that triggers DNA release. | |||
Structural changes in a marine podovirus associated with release of its genome into Prochlorococcus.,Liu X, Zhang Q, Murata K, Baker ML, Sullivan MB, Fu C, Dougherty MT, Schmid MF, Osburne MS, Chisholm SW, Chiu W Nat Struct Mol Biol. 2010 Jul;17(7):830-6. Epub 2010 Jun 13. PMID:20543830<ref>PMID:20543830</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2xd8" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</SX> | |||
[[Category: Large Structures]] | |||
[[Category: Prochlorococcus virus PSSP7]] | |||
[[Category: Baker ML]] | |||
[[Category: Chisholm SW]] | |||
[[Category: Chiu W]] | |||
[[Category: Dougherty M]] | |||
[[Category: Fu C]] | |||
[[Category: Liu X]] | |||
[[Category: Murata K]] | |||
[[Category: Osburne MS]] | |||
[[Category: Schmid MF]] | |||
[[Category: Sullivan MB]] | |||
[[Category: Zhang Q]] | |||