2xct: Difference between revisions
No edit summary |
No edit summary |
||
(2 intermediate revisions by the same user not shown) | |||
Line 1: | Line 1: | ||
==The twinned 3.35A structure of S. aureus Gyrase complex with Ciprofloxacin and DNA== | ==The twinned 3.35A structure of S. aureus Gyrase complex with Ciprofloxacin and DNA== | ||
<StructureSection load='2xct' size='340' side='right' caption='[[2xct]], [[Resolution|resolution]] 3.35Å' scene=''> | <StructureSection load='2xct' size='340' side='right'caption='[[2xct]], [[Resolution|resolution]] 3.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xct]] is a 12 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2xct]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCT FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPF:1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>CPF</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPF:1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>CPF</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xct OCA], [https://pdbe.org/2xct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xct RCSB], [https://www.ebi.ac.uk/pdbsum/2xct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xct ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [https://www.uniprot.org/uniprot/GYRA_STAAN GYRA_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01897][https://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Line 32: | Line 31: | ||
==See Also== | ==See Also== | ||
*[[Gyrase|Gyrase]] | *[[Gyrase 3D Structures|Gyrase 3D Structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bax | [[Category: Staphylococcus aureus subsp. aureus N315]] | ||
[[Category: Brown | [[Category: Synthetic construct]] | ||
[[Category: Chan | [[Category: Bax BD]] | ||
[[Category: Eggleston | [[Category: Brown KK]] | ||
[[Category: Fosberry | [[Category: Chan P]] | ||
[[Category: Gentry | [[Category: Eggleston DS]] | ||
[[Category: Giordano | [[Category: Fosberry A]] | ||
[[Category: Gorrec | [[Category: Gentry DR]] | ||
[[Category: Gwynn | [[Category: Giordano I]] | ||
[[Category: Hann | [[Category: Gorrec F]] | ||
[[Category: Hennessy | [[Category: Gwynn MN]] | ||
[[Category: Hibbs | [[Category: Hann MM]] | ||
[[Category: Huang | [[Category: Hennessy A]] | ||
[[Category: Jones | [[Category: Hibbs M]] | ||
[[Category: Jones | [[Category: Huang J]] | ||
[[Category: Lewis | [[Category: Jones E]] | ||
[[Category: May | [[Category: Jones J]] | ||
[[Category: Pearson | [[Category: Lewis CJ]] | ||
[[Category: Shen | [[Category: May E]] | ||
[[Category: Shillings | [[Category: Pearson ND]] | ||
[[Category: Singh | [[Category: Shen C]] | ||
[[Category: Spitzfaden | [[Category: Shillings A]] | ||
[[Category: Theobald | [[Category: Singh O]] | ||
[[Category: Wohlkonig | [[Category: Spitzfaden C]] | ||
[[Category: Theobald A]] | |||
[[Category: Wohlkonig A]] |