2xbn: Difference between revisions

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-==INHIBITION OF THE PLP-DEPENDENT ENZYME SERINE PALMITOYLTRANSFERASE BY CYCLOSERINE: EVIDENCE FOR A NOVEL DECARBOXYLATIVE MECHANISM OF INACTIVATION==
-<StructureSection load='2xbn' size='340' side='right' caption='[[2xbn]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
+==Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation==
+<StructureSection load='2xbn' size='340' side='right'caption='[[2xbn]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2xbn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XBN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XBN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2xbn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XBN FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2w8u|2w8u]], [[2w8v|2w8v]], [[2jgt|2jgt]], [[2w8t|2w8t]], [[2jg2|2jg2]], [[2w8j|2w8j]], [[2w8w|2w8w]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xbn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xbn RCSB], [http://www.ebi.ac.uk/pdbsum/2xbn PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xbn OCA], [https://pdbe.org/2xbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xbn RCSB], [https://www.ebi.ac.uk/pdbsum/2xbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xbn ProSAT]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SPT_SPHPI SPT_SPHPI] Catalyzes the condensation of L-serine with palmitoyl-CoA (hexadecanoyl-CoA) to produce 3-oxosphinganine (PubMed:11279212, PubMed:17557831, PubMed:17559874, PubMed:19376777). Exhibits a broad substrate specificity concerning the chain length and the degree of unsaturation of acyl-CoA (PubMed:11279212, PubMed:19376777).<ref>PMID:11279212</ref> <ref>PMID:17557831</ref> <ref>PMID:17559874</ref> <ref>PMID:19376777</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/2xbn_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/2xbn_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xbn ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 25: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2xbn" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Serine palmitoyltransferase|Serine palmitoyltransferase]]
+*[[Serine palmitoyltransferase 3D structures|Serine palmitoyltransferase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Sphingomonas paucimobilis]]
-[[Category: Bhat, V T.]]
+[[Category: Bhat VT]]
-[[Category: Campopiano, D J.]]
+[[Category: Campopiano DJ]]
-[[Category: Carter, L G.]]
+[[Category: Carter LG]]
-[[Category: Clarke, D J.]]
+[[Category: Clarke DJ]]
-[[Category: Johnson, K A.]]
+[[Category: Johnson KA]]
-[[Category: Lowther, J.]]
+[[Category: Lowther J]]
-[[Category: Mcmahon, S A.]]
+[[Category: McMahon SA]]
-[[Category: Naismith, J H.]]
+[[Category: Naismith JH]]
-[[Category: Ramakers, B.]]
+[[Category: Ramakers B]]
-[[Category: Raman, M C.C.]]
+[[Category: Raman MCC]]
-[[Category: Yard, B A.]]
+[[Category: Yard BA]]
-[[Category: Pyridoxal phosphate]]
-[[Category: Transferase]]