2wo8: Difference between revisions
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==MMP12 complex with a beta hydroxy carboxylic acid== | ==MMP12 complex with a beta hydroxy carboxylic acid== | ||
<StructureSection load='2wo8' size='340' side='right' caption='[[2wo8]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2wo8' size='340' side='right'caption='[[2wo8]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wo8]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2wo8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WO8 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=023:N^2^-[(2R)-2-{(1S)-1-[FORMYL(HYDROXY)AMINO]ETHYL}-5-PHENYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE'>023</scene>, <scene name='pdbligand=077:(3S)-5-BIPHENYL-4-YL-3-HYDROXYPENTANOIC+ACID'>077</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=023:N^2^-[(2R)-2-{(1S)-1-[FORMYL(HYDROXY)AMINO]ETHYL}-5-PHENYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE'>023</scene>, <scene name='pdbligand=077:(3S)-5-BIPHENYL-4-YL-3-HYDROXYPENTANOIC+ACID'>077</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wo8 OCA], [https://pdbe.org/2wo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wo8 RCSB], [https://www.ebi.ac.uk/pdbsum/2wo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wo8 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Matrix metalloproteinase|Matrix metalloproteinase]] | *[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Amour | [[Category: Amour AJ]] | ||
[[Category: Baddeley | [[Category: Baddeley SJ]] | ||
[[Category: Brown | [[Category: Brown D]] | ||
[[Category: Convery | [[Category: Convery MA]] | ||
[[Category: Egan | [[Category: Egan D]] | ||
[[Category: Gaines | [[Category: Gaines S]] | ||
[[Category: Gross | [[Category: Gross JW]] | ||
[[Category: Herbert | [[Category: Herbert S]] | ||
[[Category: Holmes | [[Category: Holmes IP]] | ||
[[Category: Lorthioir | [[Category: Lorthioir O]] | ||
[[Category: Martin | [[Category: Martin SL]] | ||
[[Category: Singh | [[Category: Singh OMP]] | ||
[[Category: Smith | [[Category: Smith RH]] | ||
[[Category: Strelow | [[Category: Strelow JM]] | ||
[[Category: Walker | [[Category: Walker A]] | ||
[[Category: Watson | [[Category: Watson SP]] | ||