2wdc: Difference between revisions

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-{{Seed}}
-[[Image:2wdc.png|left|200px]]
-<!--
+==Termus thermophilus Sulfate thiohydrolase SoxB in complex with glycerol==
-The line below this paragraph, containing "STRUCTURE_2wdc", creates the "Structure Box" on the page.
+<StructureSection load='2wdc' size='340' side='right'caption='[[2wdc]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2wdc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WDC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr>
-{{STRUCTURE_2wdc|  PDB=2wdc  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdc OCA], [https://pdbe.org/2wdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wdc RCSB], [https://www.ebi.ac.uk/pdbsum/2wdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wdc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q72IT0_THET2 Q72IT0_THET2]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/2wdc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wdc ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+SoxB is an essential component of the bacterial Sox sulfur oxidation pathway. SoxB contains a di-manganese(II) site and is proposed to catalyze the release of sulfate from a protein-bound cysteine S-thiosulfonate. A direct assay for SoxB activity is described. The structure of recombinant Thermus thermophilus SoxB was determined by x-ray crystallography to a resolution of 1.5 A. Structures were also determined for SoxB in complex with the substrate analogue thiosulfate and in complex with the product sulfate. A mechanistic model for SoxB is proposed based on these structures.
-===TERMUS THERMOPHILUS SULFATE THIOHYDROLASE SOXB IN COMPLEX WITH GLYCEROL===
+Mechanism for the hydrolysis of a sulfur-sulfur bond based on the crystal structure of the thiosulfohydrolase SoxB.,Sauve V, Roversi P, Leath KJ, Garman EF, Antrobus R, Lea SM, Berks BC J Biol Chem. 2009 Aug 7;284(32):21707-18. Epub 2009 Jun 16. PMID:19535341<ref>PMID:19535341</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-==About this Structure==
+</div>
-WDC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDC OCA].
+<div class="pdbe-citations 2wdc" style="background-color:#fffaf0;"></div>
-[[Category: Hydrolase]]
+== References ==
-[[Category: Thermus thermophilus]]
+<references/>
-[[Category: Antrobus, R.]]
+__TOC__
-[[Category: Berks, B C.]]
+</StructureSection>
-[[Category: Garman, E F.]]
+[[Category: Large Structures]]
-[[Category: Lea, S M.]]
+[[Category: Thermus thermophilus HB27]]
-[[Category: Leath, K.]]
+[[Category: Antrobus R]]
-[[Category: Roversi, P.]]
+[[Category: Berks BC]]
-[[Category: Sauve, V.]]
+[[Category: Garman EF]]
-[[Category: Cys s-thiosulfonate]]
+[[Category: Lea SM]]
-[[Category: Hydrolase]]
+[[Category: Leath KJ]]
-[[Category: Sox]]
+[[Category: Roversi P]]
-[[Category: Soxb]]
+[[Category: Sauve V]]
-[[Category: Sulfur oxidation pathway]]
-[[Category: Sulfur-sulfur hydrolysis]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  1 20:27:39 2009''