2uv7: Difference between revisions

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-==CRYSTAL STRUCTURE OF A CBS DOMAIN PAIR FROM THE REGULATORY GAMMA1 SUBUNIT OF HUMAN AMPK IN COMPLEX WITH AMP==
+==Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP==
-<StructureSection load='2uv7' size='340' side='right' caption='[[2uv7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='2uv7' size='340' side='right'caption='[[2uv7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2uv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UV7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2uv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UV7 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uv4|2uv4]], [[2uv5|2uv5]], [[2uv6|2uv6]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uv7 OCA], [http://pdbe.org/2uv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uv7 RCSB], [http://www.ebi.ac.uk/pdbsum/2uv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uv7 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uv7 OCA], [https://pdbe.org/2uv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uv7 RCSB], [https://www.ebi.ac.uk/pdbsum/2uv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uv7 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/AAKG1_HUMAN AAKG1_HUMAN] AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.<ref>PMID:21680840</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uv7_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uv7_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 29: / Line 31: @@
 ==See Also==
-*[[AMP-activated protein kinase|AMP-activated protein kinase]]
+*[[AMP-activated protein kinase 3D structures|AMP-activated protein kinase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Cleasby, A]]
+[[Category: Large Structures]]
-[[Category: Day, P]]
+[[Category: Cleasby A]]
-[[Category: Horer, S]]
+[[Category: Day P]]
-[[Category: Nar, H]]
+[[Category: Horer S]]
-[[Category: Parra, L]]
+[[Category: Nar H]]
-[[Category: Redemann, N]]
+[[Category: Parra L]]
-[[Category: Sharff, A]]
+[[Category: Redemann N]]
-[[Category: Tickle, I]]
+[[Category: Sharff A]]
-[[Category: Williams, M]]
+[[Category: Tickle I]]
-[[Category: Yon, J]]
+[[Category: Williams M]]
-[[Category: Ampk gamma1 subunit cbs 3 plus 4 amp regulatory subunit. r transferase]]
+[[Category: Yon J]]
-[[Category: Cbs domain]]
-[[Category: Fatty acid biosynthesis]]
-[[Category: Lipid synthesis]]
-[[Category: Transferase]]