2ku5: Difference between revisions
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==Mouse Prion Protein (121-231) with mutation D167S== | ==Mouse Prion Protein (121-231) with mutation D167S== | ||
<StructureSection load='2ku5' size='340' side='right'caption='[[2ku5 | <StructureSection load='2ku5' size='340' side='right'caption='[[2ku5]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ku5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ku5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KU5 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ku5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ku5 OCA], [https://pdbe.org/2ku5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ku5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ku5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ku5 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ku5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ku5 OCA], [https://pdbe.org/2ku5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ku5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ku5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ku5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Damberger | [[Category: Damberger FF]] | ||
[[Category: Perez | [[Category: Perez DR]] | ||
[[Category: Wuthrich | [[Category: Wuthrich K]] | ||