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==Solution NMR Structure of the SH3 Domain from the p85beta subunit of Phosphatidylinositol 3-kinase from H.sapiens, Northeast Structural Genomics Consortium Target HR5531E==
==Solution NMR Structure of the SH3 Domain from the p85beta subunit of Phosphatidylinositol 3-kinase from H.sapiens, Northeast Structural Genomics Consortium Target HR5531E==
<StructureSection load='2kt1' size='340' side='right' caption='[[2kt1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2kt1' size='340' side='right'caption='[[2kt1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kt1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KT1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kt1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KT1 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIK3R2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kt1 OCA], [http://pdbe.org/2kt1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kt1 RCSB], [http://www.ebi.ac.uk/pdbsum/2kt1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kt1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kt1 OCA], [https://pdbe.org/2kt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kt1 RCSB], [https://www.ebi.ac.uk/pdbsum/2kt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kt1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/P85B_HUMAN P85B_HUMAN]] Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.  
[https://www.uniprot.org/uniprot/P85B_HUMAN P85B_HUMAN] Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Phosphoinositide 3-Kinases|Phosphoinositide 3-Kinases]]
*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Aramini, J M]]
[[Category: Large Structures]]
[[Category: Everett, J K]]
[[Category: Aramini JM]]
[[Category: Ma, L]]
[[Category: Everett JK]]
[[Category: Montelione, G T]]
[[Category: Ma L]]
[[Category: Structural genomic]]
[[Category: Montelione GT]]
[[Category: Schauder, C]]
[[Category: Schauder C]]
[[Category: P85beta subunit of pi3k]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protein binding]]
[[Category: PSI, Protein structure initiative]]
[[Category: Sh3 domain]]
[[Category: Target hr5531e]]

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