2krr: Difference between revisions
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==Solution structure of the RBD1,2 domains from human nucleolin== | ==Solution structure of the RBD1,2 domains from human nucleolin== | ||
<StructureSection load='2krr' size='340' side='right' caption='[[2krr | <StructureSection load='2krr' size='340' side='right'caption='[[2krr]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2krr]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2krr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KRR FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2krr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2krr OCA], [https://pdbe.org/2krr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2krr RCSB], [https://www.ebi.ac.uk/pdbsum/2krr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2krr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NUCL_HUMAN NUCL_HUMAN] Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.<ref>PMID:10393184</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Arumugam | [[Category: Large Structures]] | ||
[[Category: Bates | [[Category: Arumugam N]] | ||
[[Category: Lane | [[Category: Bates PJ]] | ||
[[Category: Maliekal | [[Category: Lane AN]] | ||
[[Category: Miller | [[Category: Maliekal J]] | ||
[[Category: Trent | [[Category: Miller C]] | ||
[[Category: Trent JO]] | |||
Latest revision as of 12:51, 9 May 2024
Solution structure of the RBD1,2 domains from human nucleolinSolution structure of the RBD1,2 domains from human nucleolin
Structural highlights
FunctionNUCL_HUMAN Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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