2kpp: Difference between revisions

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-{{Seed}}
-[[Image:2kpp.png|left|200px]]
-<!--
+==Solution NMR structure of Lin0431 protein from Listeria innocua. Northeast Structural Genomics Consortium Target LkR112==
-The line below this paragraph, containing "STRUCTURE_2kpp", creates the "Structure Box" on the page.
+<StructureSection load='2kpp' size='340' side='right'caption='[[2kpp]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2kpp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_innocua Listeria innocua]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KPP FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpp OCA], [https://pdbe.org/2kpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kpp RCSB], [https://www.ebi.ac.uk/pdbsum/2kpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kpp ProSAT]</span></td></tr>
-{{STRUCTURE_2kpp|  PDB=2kpp  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q92EM7_LISIN Q92EM7_LISIN]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/2kpp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kpp ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Lin0431 protein from Listeria innocua (UniProtKB/TrEMBL ID Q92EM7/Q92EM7_LISIN) was selected as a target of the Northeast Structural Genomics Consortium (target ID: LkR112). Here, we present the high-quality NMR solution structure of this protein which is the first representative for a member of DUF1312 domain family. Lin0431 protein exhibits a beta-sandwich topology. Four anti-parallel beta-strands form one face of the sandwich and the other three anti-parallel beta-strands together with a short alpha-helix form the other face of the sandwich. Structure alignment by Dali reveals an unexpected structural similarity with domain II of NusG from Aquifex aeolicus. Analyses of the electrostatic protein surface potential and searches for protein surface cavities reveal the conserved basic charged surface cavities of both the Lin0431 and domain II of AaeNusG, suggesting they may bind the negatively charged nucleic acids and/or and other binding partners. The high structural similarity and similar surface features, despite the lack of recognizable sequence similarity, between Lin0431 and AaeNusG domain II suggest that the domain II of NusG and DUF1312 domains have a homologous relationship and may share similar biochemical functions.
-===Solution NMR structure of Lin0431 protein from Listeria innocua. Northeast Structural Genomics Consortium Target LkR112===
+Solution NMR structure of Lin0431 protein from Listeria innocua reveals high structural similarity with domain II of bacterial transcription antitermination protein NusG.,Tang Y, Xiao R, Ciccosanti C, Janjua H, Lee DY, Everett JK, Swapna GV, Acton TB, Rost B, Montelione GT Proteins. 2010 Aug 15;78(11):2563-8. doi: 10.1002/prot.22760. PMID:20602357<ref>PMID:20602357</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-==About this Structure==
+</div>
-KPP is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_innocua Listeria innocua]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPP OCA].
+<div class="pdbe-citations 2kpp" style="background-color:#fffaf0;"></div>
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:20602357</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Listeria innocua]]
-[[Category: Acton, T B.]]
+[[Category: Acton TB]]
-[[Category: Ciccosanti, C.]]
+[[Category: Ciccosanti C]]
-[[Category: Everett, J K.]]
+[[Category: Everett JK]]
-[[Category: Janjua, H.]]
+[[Category: Janjua H]]
-[[Category: Lee, D Y.]]
+[[Category: Lee DY]]
-[[Category: Montelione, G T.]]
+[[Category: Montelione GT]]
-[[Category: NESG, Northeast Structural Genomics Consortium.]]
+[[Category: Rost B]]
-[[Category: Rost, B.]]
+[[Category: Swapna GVT]]
-[[Category: Swapna, G V.T.]]
+[[Category: Tang Y]]
-[[Category: Tang, Y.]]
+[[Category: Xiao R]]
-[[Category: Xiao, R.]]
-[[Category: Nesg]]
-[[Category: Northeast structural genomics consortium]]
-[[Category: Protein structure initiative]]
-[[Category: Psi-2]]
-[[Category: Solution nmr structure]]
-[[Category: Structural genomic]]
-[[Category: Unknown function]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 09:55:30 2010''