2kdd: Difference between revisions

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==Solution structure of the conserved C-terminal dimerization domain of Borealin==
==Solution structure of the conserved C-terminal dimerization domain of Borealin==
<StructureSection load='2kdd' size='340' side='right'caption='[[2kdd]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2kdd' size='340' side='right'caption='[[2kdd]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kdd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KDD FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kdd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KDD FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDCA8, PESCRG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kdd OCA], [http://pdbe.org/2kdd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kdd RCSB], [http://www.ebi.ac.uk/pdbsum/2kdd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kdd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kdd OCA], [https://pdbe.org/2kdd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kdd RCSB], [https://www.ebi.ac.uk/pdbsum/2kdd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kdd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BOREA_HUMAN BOREA_HUMAN]] Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.<ref>PMID:15260989</ref> <ref>PMID:15249581</ref> <ref>PMID:16571674</ref> <ref>PMID:18243099</ref>
[https://www.uniprot.org/uniprot/BOREA_HUMAN BOREA_HUMAN] Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.<ref>PMID:15260989</ref> <ref>PMID:15249581</ref> <ref>PMID:16571674</ref> <ref>PMID:18243099</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bourhis, E]]
[[Category: Bourhis E]]
[[Category: Cochran, A G]]
[[Category: Cochran AG]]
[[Category: Fairbrother, W J]]
[[Category: Fairbrother WJ]]
[[Category: Lingel, A]]
[[Category: Lingel A]]
[[Category: Cell cycle]]
[[Category: Cell division]]
[[Category: Centromere]]
[[Category: Chromosomal protein]]
[[Category: Cytoplasm]]
[[Category: Mitosis]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protein dimer]]

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