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==Crystal Structure of a family GT4 glycosyltransferase from Bacillus anthracis ORF BA1558.==
==Crystal Structure of a family GT4 glycosyltransferase from Bacillus anthracis ORF BA1558.==
<StructureSection load='2jjm' size='340' side='right' caption='[[2jjm]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='2jjm' size='340' side='right'caption='[[2jjm]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jjm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJM FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jjm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._Ames Bacillus anthracis str. Ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJM FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjm OCA], [http://pdbe.org/2jjm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jjm RCSB], [http://www.ebi.ac.uk/pdbsum/2jjm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjm ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjm OCA], [https://pdbe.org/2jjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jjm RCSB], [https://www.ebi.ac.uk/pdbsum/2jjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BSHA_BACAN BSHA_BACAN] Involved in bacillithiol (BSH) biosynthesis. Catalyzes the first step of the pathway, the formation of N-acetylglucosaminylmalate (GlcNAc-Mal) from UDP-N-acetylglucosamine (UDP-GlcNAc) and L-malate.<ref>PMID:20799687</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjm_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjm_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 16: Line 19:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jjm ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jjm ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Davies, G J]]
[[Category: Bacillus anthracis str. Ames]]
[[Category: Martinez-Fleites, C]]
[[Category: Large Structures]]
[[Category: Ruane, K M]]
[[Category: Davies GJ]]
[[Category: Anthrax]]
[[Category: Martinez-Fleites C]]
[[Category: Carbohydrate]]
[[Category: Ruane KM]]
[[Category: Glycosyl transfer]]
[[Category: Glycosyltransferase]]
[[Category: Nucleotide]]
[[Category: Transferase]]

Latest revision as of 12:38, 9 May 2024

Crystal Structure of a family GT4 glycosyltransferase from Bacillus anthracis ORF BA1558.Crystal Structure of a family GT4 glycosyltransferase from Bacillus anthracis ORF BA1558.

Structural highlights

2jjm is a 12 chain structure with sequence from Bacillus anthracis str. Ames. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.1Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BSHA_BACAN Involved in bacillithiol (BSH) biosynthesis. Catalyzes the first step of the pathway, the formation of N-acetylglucosaminylmalate (GlcNAc-Mal) from UDP-N-acetylglucosamine (UDP-GlcNAc) and L-malate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A. Characterization of the N-acetyl-alpha-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry. 2010 Sep 28;49(38):8398-414. PMID:20799687 doi:10.1021/bi100698n

2jjm, resolution 3.10Å

Drag the structure with the mouse to rotate

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OCA
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