2jhc: Difference between revisions

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[[Image:2jhc.png|left|200px]]


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==The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line==
The line below this paragraph, containing "STRUCTURE_2jhc", creates the "Structure Box" on the page.
<StructureSection load='2jhc' size='340' side='right'caption='[[2jhc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jhc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bluetongue_virus_(serotype_10_/_American_isolate) Bluetongue virus (serotype 10 / American isolate)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JHC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
{{STRUCTURE_2jhc|  PDB=2jhc  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhc OCA], [https://pdbe.org/2jhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jhc RCSB], [https://www.ebi.ac.uk/pdbsum/2jhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VP4_BTV10 VP4_BTV10] The VP4 protein is one of the five proteins (with VP1, VP3, VP6 and VP7) which form the inner capsid of the virus.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jhc ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.


===THE STRUCTURE OF BLUETONGUE VIRUS VP4 REVEALS A MULTIFUNCTIONAL RNA-CAPPING PRODUCTION-LINE===
Bluetongue virus VP4 is an RNA-capping assembly line.,Sutton G, Grimes JM, Stuart DI, Roy P Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:17417654<ref>PMID:17417654</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2jhc" style="background-color:#fffaf0;"></div>


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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 17417654 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_17417654}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2JHC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bluetongue_virus_10_(isolate_usa) Bluetongue virus 10 (isolate usa)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHC OCA].
[[Category: Grimes JM]]
 
[[Category: Roy P]]
==Reference==
[[Category: Stuart DI]]
<ref group="xtra">PMID:17417654</ref><references group="xtra"/>
[[Category: Sutton G]]
[[Category: Grimes, J M.]]
[[Category: Roy, P.]]
[[Category: Stuart, D I.]]
[[Category: Sutton, G.]]
[[Category: Core protein]]
[[Category: Guanylyltransferase]]
[[Category: Methyltransferase]]
[[Category: Viral capping enzyme]]
[[Category: Viral protein]]
[[Category: Virion protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:28:08 2009''

Latest revision as of 12:37, 9 May 2024

The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-lineThe structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line

Structural highlights

2jhc is a 1 chain structure with sequence from Bluetongue virus (serotype 10 / American isolate). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VP4_BTV10 The VP4 protein is one of the five proteins (with VP1, VP3, VP6 and VP7) which form the inner capsid of the virus.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.

Bluetongue virus VP4 is an RNA-capping assembly line.,Sutton G, Grimes JM, Stuart DI, Roy P Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:17417654[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Sutton G, Grimes JM, Stuart DI, Roy P. Bluetongue virus VP4 is an RNA-capping assembly line. Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:17417654 doi:10.1038/nsmb1225

2jhc, resolution 3.00Å

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