2jak: Difference between revisions
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== | |||
<StructureSection load='2jak' size='340' side='right' caption='[[2jak]], [[Resolution|resolution]] 2.60Å' scene=''> | ==Human PP2A regulatory subunit B56g== | ||
<StructureSection load='2jak' size='340' side='right'caption='[[2jak]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jak]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2jak]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAK FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jak OCA], [https://pdbe.org/2jak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jak RCSB], [https://www.ebi.ac.uk/pdbsum/2jak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jak ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/2A5G_HUMAN 2A5G_HUMAN] The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.<ref>PMID:16456541</ref> <ref>PMID:17245430</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jak_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jak_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jak ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2jak" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Protein phosphatase|Protein phosphatase | *[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 32: | Line 36: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith C]] | ||
[[Category: Berglund | [[Category: Berglund H]] | ||
[[Category: Busam | [[Category: Busam R]] | ||
[[Category: Collins | [[Category: Collins R]] | ||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Ericsson | [[Category: Ericsson UB]] | ||
[[Category: Flodin | [[Category: Flodin S]] | ||
[[Category: Flores | [[Category: Flores A]] | ||
[[Category: Graslund | [[Category: Graslund S]] | ||
[[Category: Hallberg | [[Category: Hallberg BM]] | ||
[[Category: Hammarstrom | [[Category: Hammarstrom M]] | ||
[[Category: Hogbom | [[Category: Hogbom M]] | ||
[[Category: Johansson | [[Category: Holmberg Schiavone L]] | ||
[[Category: Karlberg | [[Category: Johansson I]] | ||
[[Category: Kotenyova | [[Category: Karlberg T]] | ||
[[Category: Lundgren | [[Category: Kotenyova T]] | ||
[[Category: Magnusdottir | [[Category: Lundgren S]] | ||
[[Category: Moche | [[Category: Magnusdottir A]] | ||
[[Category: Nilsson | [[Category: Moche M]] | ||
[[Category: Nordlund | [[Category: Nilsson P]] | ||
[[Category: Nyman | [[Category: Nordlund P]] | ||
[[Category: Ogg | [[Category: Nyman T]] | ||
[[Category: Persson | [[Category: Ogg D]] | ||
[[Category: Sagemark | [[Category: Persson C]] | ||
[[Category: Sagemark J]] | |||
[[Category: Stenmark | [[Category: Stenmark P]] | ||
[[Category: Sundstrom | [[Category: Sundstrom M]] | ||
[[Category: Thorsell | [[Category: Thorsell AG]] | ||
[[Category: Uppenberg | [[Category: Uppenberg J]] | ||
[[Category: Upsten | [[Category: Upsten M]] | ||
[[Category: | [[Category: Van Den Berg S]] | ||
[[Category: | [[Category: Weigelt J]] | ||