2cl3: Difference between revisions

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-{{Seed}}
-[[Image:2cl3.png|left|200px]]
-<!--
+==Crystal structure of human Cleavage and Polyadenylation Specificity Factor 5 (CPSF5)==
-The line below this paragraph, containing "STRUCTURE_2cl3", creates the "Structure Box" on the page.
+<StructureSection load='2cl3' size='340' side='right'caption='[[2cl3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2cl3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CL3 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cl3 OCA], [https://pdbe.org/2cl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cl3 RCSB], [https://www.ebi.ac.uk/pdbsum/2cl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cl3 ProSAT]</span></td></tr>
-{{STRUCTURE_2cl3|  PDB=2cl3  |  SCENE=  }}
+</table>
+== Function ==
-===CRYSTAL STRUCTURE OF HUMAN CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 5 (CPSF5)===
+[https://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==About this Structure==
+Check<jmol>
-CL3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CL3 OCA].
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/2cl3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cl3 ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C.]]
+[[Category: Large Structures]]
-[[Category: Berg, S Van Den.]]
+[[Category: Arrowsmith C]]
-[[Category: Berglund, H.]]
+[[Category: Berglund H]]
-[[Category: Collins, R.]]
+[[Category: Collins R]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Ehn, M.]]
+[[Category: Ehn M]]
-[[Category: Flodin, S.]]
+[[Category: Flodin S]]
-[[Category: Flores, A.]]
+[[Category: Flores A]]
-[[Category: Graslund, S.]]
+[[Category: Graslund S]]
-[[Category: Hallberg, B M.]]
+[[Category: Hallberg BM]]
-[[Category: Hammarstrom, M.]]
+[[Category: Hammarstrom M]]
-[[Category: Hogbom, M.]]
+[[Category: Hogbom M]]
-[[Category: Kotenyova, T.]]
+[[Category: Holmberg Schiavone L]]
-[[Category: Magnusdottir, A.]]
+[[Category: Kotenyova T]]
-[[Category: Nilsson-Ehle, P.]]
+[[Category: Magnusdottir A]]
-[[Category: Nordlund, P.]]
+[[Category: Nilsson-Ehle P]]
-[[Category: Nyman, T.]]
+[[Category: Nordlund P]]
-[[Category: Ogg, D.]]
+[[Category: Nyman T]]
-[[Category: Persson, C.]]
+[[Category: Ogg D]]
-[[Category: Sagemark, J.]]
+[[Category: Persson C]]
-[[Category: Schiavone, L Holmberg.]]
+[[Category: Sagemark J]]
-[[Category: Stenmark, P.]]
+[[Category: Stenmark P]]
-[[Category: Sundstrom, M.]]
+[[Category: Sundstrom M]]
-[[Category: Thorsell, A G.]]
+[[Category: Thorsell AG]]
-[[Category: Wallden, K.]]
+[[Category: Van Den Berg S]]
-[[Category: Weigelt, J.]]
+[[Category: Wallden K]]
-[[Category: Cfim25]]
+[[Category: Weigelt J]]
-[[Category: Cleavage and polyadenylation specificity factor 5]]
-[[Category: Cpsf5]]
-[[Category: Mrna]]
-[[Category: Mrna processing]]
-[[Category: Nuclear protein]]
-[[Category: Phosphorylation]]
-[[Category: Precursor mrna cleavage factor im]]
-[[Category: Rna-binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:00:15 2009''