2c7n: Difference between revisions
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<StructureSection load='2c7n' size='340' side='right'caption='[[2c7n]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='2c7n' size='340' side='right'caption='[[2c7n]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2c7n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2c7n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C7N FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7n OCA], [https://pdbe.org/2c7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c7n RCSB], [https://www.ebi.ac.uk/pdbsum/2c7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7n ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7n OCA], [https://pdbe.org/2c7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c7n RCSB], [https://www.ebi.ac.uk/pdbsum/2c7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RABX5_HUMAN RABX5_HUMAN] Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).<ref>PMID:9323142</ref> <ref>PMID:11452015</ref> <ref>PMID:15339665</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bos taurus]] | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Confalioneri | [[Category: Confalioneri S]] | ||
[[Category: Fiore | [[Category: Di Fiore PP]] | ||
[[Category: Magri | [[Category: Magri L]] | ||
[[Category: Mapelli | [[Category: Mapelli M]] | ||
[[Category: Murachelli | [[Category: Murachelli AG]] | ||
[[Category: Musacchio | [[Category: Musacchio A]] | ||
[[Category: Penengo | [[Category: Penengo L]] | ||
[[Category: Polo | [[Category: Polo S]] | ||
[[Category: Schneider | [[Category: Schneider TR]] | ||