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==The structure of Hydroxypropylphosphonic acid epoxidase from S. wedmorenis.==
==The structure of Hydroxypropylphosphonic acid epoxidase from S. wedmorenis.==
<StructureSection load='2bno' size='340' side='right' caption='[[2bno]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2bno' size='340' side='right'caption='[[2bno]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bno]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BNO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BNO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bno]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BNO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BNO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zz9|1zz9]], [[2bnm|2bnm]], [[1zz7|1zz7]], [[1zz6|1zz6]], [[1zz8|1zz8]], [[1zzb|1zzb]], [[1zzc|1zzc]], [[2bnn|2bnn]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bno OCA], [http://pdbe.org/2bno PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bno RCSB], [http://www.ebi.ac.uk/pdbsum/2bno PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bno ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bno OCA], [https://pdbe.org/2bno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bno RCSB], [https://www.ebi.ac.uk/pdbsum/2bno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bno ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HPPE_STRWE HPPE_STRWE] Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)-epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic.<ref>PMID:16015285</ref> <ref>PMID:16186494</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/2bno_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/2bno_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2bno" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2bno" style="background-color:#fffaf0;"></div>
==See Also==
*[[Epoxidase 3D structures|Epoxidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cameron, S]]
[[Category: Large Structures]]
[[Category: Hunter, W N]]
[[Category: Streptomyces wedmorensis]]
[[Category: McLuskey, K]]
[[Category: Cameron S]]
[[Category: Cation-dependant]]
[[Category: Hunter WN]]
[[Category: Cupin]]
[[Category: McLuskey K]]
[[Category: Epoxidase]]
[[Category: Fosfomycin]]
[[Category: Hth]]
[[Category: Oxidoreductase]]
[[Category: Zinc]]

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