2blb: Difference between revisions

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 ==X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative==
-<StructureSection load='2blb' size='340' side='right' caption='[[2blb]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+<StructureSection load='2blb' size='340' side='right'caption='[[2blb]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2blb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BLB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2blb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BLB FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CP7:6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE'>CP7</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bl9|2bl9]], [[2bla|2bla]], [[2blc|2blc]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP7:6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE'>CP7</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2blb OCA], [https://pdbe.org/2blb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2blb RCSB], [https://www.ebi.ac.uk/pdbsum/2blb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2blb ProSAT], [https://www.topsan.org/Proteins/RSGI/2blb TOPSAN]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2blb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2blb OCA], [http://pdbe.org/2blb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2blb RCSB], [http://www.ebi.ac.uk/pdbsum/2blb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2blb ProSAT], [http://www.topsan.org/Proteins/RSGI/2blb TOPSAN]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/DRTS_PLAVI DRTS_PLAVI] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/2blb_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/2blb_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 28: / Line 29: @@
 </div>
 <div class="pdbe-citations 2blb" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Dihydrofolate reductase]]
+[[Category: Large Structures]]
-[[Category: Chitnumsub, P]]
+[[Category: Plasmodium vivax]]
-[[Category: Khongsuk, P]]
+[[Category: Chitnumsub P]]
-[[Category: Kongsaeree, P]]
+[[Category: Khongsuk P]]
-[[Category: Leartsakulpanich, U]]
+[[Category: Kongsaeree P]]
-[[Category: Tarnchompoo, B]]
+[[Category: Leartsakulpanich U]]
-[[Category: Walkinshaw, M D]]
+[[Category: Tarnchompoo B]]
-[[Category: Yuthavong, Y]]
+[[Category: Walkinshaw MD]]
-[[Category: Drug resistance]]
+[[Category: Yuthavong Y]]
-[[Category: Malaria]]
-[[Category: Oxidoreductase]]
-[[Category: Plamodium vivax]]
-[[Category: Pyrimethamine]]