2bk1: Difference between revisions

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OCA

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 ==The pore structure of pneumolysin, obtained by fitting the alpha carbon trace of perfringolysin O into a cryo-EM map==
-<StructureSection load='2bk1' size='340' side='right' caption='[[2bk1]], [[Resolution|resolution]] 29.00&Aring;' scene=''>
+<SX load='2bk1' size='340' side='right' viewer='molstar' caption='[[2bk1]], [[Resolution|resolution]] 29.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2bk1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BK1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2bk1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BK1 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m3i|1m3i]], [[1m3j|1m3j]], [[1pfo|1pfo]], [[2bk2|2bk2]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 29&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bk1 RCSB], [http://www.ebi.ac.uk/pdbsum/2bk1 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk1 OCA], [https://pdbe.org/2bk1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bk1 RCSB], [https://www.ebi.ac.uk/pdbsum/2bk1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bk1 ProSAT]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TACY_CLOPE TACY_CLOPE] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation.<ref>PMID:17328912</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/2bk1_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/2bk1_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bk1 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 24: / Line 27: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2bk1" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Cytolysin 3D structures|Cytolysin 3D structures]]
 == References ==
 <references/>
 __TOC__
-</StructureSection>
+</SX>
 [[Category: Clostridium perfringens]]
-[[Category: Andrew, P W.]]
+[[Category: Large Structures]]
-[[Category: Gilbert, R J.C.]]
+[[Category: Andrew PW]]
-[[Category: Orlova, E V.]]
+[[Category: Gilbert RJC]]
-[[Category: Saibil, H R.]]
+[[Category: Orlova EV]]
-[[Category: Tilley, S J.]]
+[[Category: Saibil HR]]
-[[Category: Cryoem]]
+[[Category: Tilley SJ]]
-[[Category: Cytolysis]]
-[[Category: Cytolytic protein]]
-[[Category: Hemolysis]]
-[[Category: Thiol-activated cytolysin]]
-[[Category: Toxin]]