2ajj: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==NMR structure of the in-plane membrane anchor domain [1-28] of the monotopic Non Structural Protein 5A (NS5A) of Bovine Viral Diarrhea Virus (BVDV)==
-<StructureSection load='2ajj' size='340' side='right' caption='[[2ajj]], [[NMR_Ensembles_of_Models | 31 NMR models]]' scene=''>
+<StructureSection load='2ajj' size='340' side='right'caption='[[2ajj]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ajj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AJJ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ajj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1-CP7 Bovine viral diarrhea virus 1-CP7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AJJ FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ajn|2ajn]], [[2ajm|2ajm]], [[2ajo|2ajo]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ajj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ajj RCSB], [http://www.ebi.ac.uk/pdbsum/2ajj PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ajj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajj OCA], [https://pdbe.org/2ajj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ajj RCSB], [https://www.ebi.ac.uk/pdbsum/2ajj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajj ProSAT]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/POLG_BVDVC POLG_BVDVC] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (By similarity).  P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity).  Uncleaved NS2-3 is required for production of infectious virus.  NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.  NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase.  NS4A is a cofactor for the NS3 protease activity (By similarity).  RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 14: / Line 17: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2ajj" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Nonstructural protein|Nonstructural protein]]
+*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Brass, V.]]
+[[Category: Bovine viral diarrhea virus 1-CP7]]
-[[Category: Chipot, C.]]
+[[Category: Large Structures]]
-[[Category: Deleage, G.]]
+[[Category: Brass V]]
-[[Category: Montserret, R.]]
+[[Category: Chipot C]]
-[[Category: Moradpour, D.]]
+[[Category: Deleage G]]
-[[Category: Penin, F.]]
+[[Category: Montserret R]]
-[[Category: Sapay, N.]]
+[[Category: Moradpour D]]
-[[Category: Amphipathic alpha-helix]]
+[[Category: Penin F]]
-[[Category: In-plane membrane anchor domain]]
+[[Category: Sapay N]]
-[[Category: Membrane protein]]