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==STRUCTURE BASED ENGINEERING OF INTERNAL MOLECULAR SURFACES OF FOUR HELIX BUNDLES==
 
<StructureSection load='1uo5' size='340' side='right' caption='[[1uo5]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
==Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles==
<StructureSection load='1uo5' size='340' side='right'caption='[[1uo5]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1uo5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UO5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1uo5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UO5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PIH:IODOPHENYL'>PIH</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gcl|1gcl]], [[1gcm|1gcm]], [[1unt|1unt]], [[1unv|1unv]], [[1unw|1unw]], [[1unx|1unx]], [[1unu|1unu]], [[1uny|1uny]], [[1unz|1unz]], [[1uo0|1uo0]], [[1uo1|1uo1]], [[1uo2|1uo2]], [[1uo3|1uo3]], [[1uo4|1uo4]], [[1ce9|1ce9]], [[1dgc|1dgc]], [[1env|1env]], [[1fav|1fav]], [[1gk6|1gk6]], [[1gzl|1gzl]], [[1ihq|1ihq]], [[1ij0|1ij0]], [[1ij1|1ij1]], [[1ij2|1ij2]], [[1ij3|1ij3]], [[1kql|1kql]], [[1ld4|1ld4]], [[1llm|1llm]], [[1nkn|1nkn]], [[1piq|1piq]], [[1rb1|1rb1]], [[1rb4|1rb4]], [[1rb5|1rb5]], [[1rb6|1rb6]], [[1swi|1swi]], [[1tmz|1tmz]], [[1w5g|1w5g]], [[1w5h|1w5h]], [[1w5i|1w5i]], [[1w5j|1w5j]], [[1w5k|1w5k]], [[1w5l|1w5l]], [[1ysa|1ysa]], [[1zii|1zii]], [[1zij|1zij]], [[1zik|1zik]], [[1zil|1zil]], [[1zim|1zim]], [[1zta|1zta]], [[2dgc|2dgc]], [[2zta|2zta]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [https://pdbe.org/1uo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [https://www.ebi.ac.uk/pdbsum/1uo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uo5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uo5 OCA], [http://pdbe.org/1uo5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1uo5 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Gcn4|Gcn4]]
*[[Gcn4 3D Structures|Gcn4 3D Structures]]
*[[Gnc4 3D Structures|Gnc4 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alvarez-Gutierrez, J M]]
[[Category: Large Structures]]
[[Category: Redman, J E]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Yadav, M K]]
[[Category: Alvarez-Gutierrez JM]]
[[Category: Zhang, Y]]
[[Category: Redman JE]]
[[Category: Cavity]]
[[Category: Yadav MK]]
[[Category: Four helix bundle]]
[[Category: Zhang Y]]
[[Category: Iodobenzene]]

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