1og5: Difference between revisions

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 <StructureSection load='1og5' size='340' side='right'caption='[[1og5]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1og5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OG5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1og5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OG5 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=SWF:S-WARFARIN'>SWF</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1og2|1og2]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=SWF:S-WARFARIN'>SWF</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1og5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1og5 OCA], [http://pdbe.org/1og5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1og5 RCSB], [http://www.ebi.ac.uk/pdbsum/1og5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1og5 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1og5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1og5 OCA], [https://pdbe.org/1og5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1og5 RCSB], [https://www.ebi.ac.uk/pdbsum/1og5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1og5 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/CP2C9_HUMAN CP2C9_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 35: / Line 37: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Angove, H C]]
+[[Category: Angove HC]]
-[[Category: Cosme, J]]
+[[Category: Cosme J]]
-[[Category: Jhoti, H]]
+[[Category: Jhoti H]]
-[[Category: Vinkovic, D Matak]]
+[[Category: Matak Vinkovic D]]
-[[Category: Ward, A]]
+[[Category: Ward A]]
-[[Category: Williams, P A]]
+[[Category: Williams PA]]
-[[Category: Drug metabolism]]
-[[Category: Electron transport]]
-[[Category: Heme]]
-[[Category: Monooxygenase]]
-[[Category: Oxidoreductase]]