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1e2g: Difference between revisions

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==Human thymidylate kinase complexed with ADP, TDP and a magnesium-ion==
==Human thymidylate kinase complexed with ADP, TDP and a magnesium-ion==
<StructureSection load='1e2g' size='340' side='right' caption='[[1e2g]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='1e2g' size='340' side='right'caption='[[1e2g]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1e2g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E2G FirstGlance]. <br>
<table><tr><td colspan='2'>[[1e2g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E2G FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene>, <scene name='pdbligand=TYD:THYMIDINE-5-DIPHOSPHATE'>TYD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e2d|1e2d]], [[1e9a|1e9a]], [[1e9b|1e9b]], [[1nn3|1nn3]], [[1e98|1e98]], [[1e2e|1e2e]], [[1e9e|1e9e]], [[1e2q|1e2q]], [[1nmx|1nmx]], [[1e99|1e99]], [[1nn5|1nn5]], [[1nn1|1nn1]], [[1nmz|1nmz]], [[2xx3|2xx3]], [[1e9d|1e9d]], [[1e2f|1e2f]], [[1nmy|1nmy]], [[1e9f|1e9f]], [[1nn0|1nn0]], [[1e9c|1e9c]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene>, <scene name='pdbligand=TYD:THYMIDINE-5-DIPHOSPHATE'>TYD</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2g OCA], [https://pdbe.org/1e2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e2g RCSB], [https://www.ebi.ac.uk/pdbsum/1e2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e2g ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2g OCA], [http://pdbe.org/1e2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e2g RCSB], [http://www.ebi.ac.uk/pdbsum/1e2g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e2g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KTHY_HUMAN KTHY_HUMAN]] Catalyzes the conversion of dTMP to dTDP.  
[https://www.uniprot.org/uniprot/KTHY_HUMAN KTHY_HUMAN] Catalyzes the conversion of dTMP to dTDP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/1e2g_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/1e2g_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: DTMP kinase]]
[[Category: Homo sapiens]]
[[Category: Brundiers, R]]
[[Category: Large Structures]]
[[Category: Goody, R S]]
[[Category: Brundiers R]]
[[Category: Konrad, M]]
[[Category: Goody RS]]
[[Category: Lavie, A]]
[[Category: Konrad M]]
[[Category: Ostermann, N]]
[[Category: Lavie A]]
[[Category: Reinstein, J]]
[[Category: Ostermann N]]
[[Category: Schlichting, I]]
[[Category: Reinstein J]]
[[Category: Veit, T]]
[[Category: Schlichting I]]
[[Category: P-loop]]
[[Category: Veit T]]
[[Category: Transferase]]

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