1rfh: Difference between revisions
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==Solution structure of the C1 domain of Nore1, a novel Ras effector== | ==Solution structure of the C1 domain of Nore1, a novel Ras effector== | ||
<StructureSection load='1rfh' size='340' side='right'caption='[[1rfh | <StructureSection load='1rfh' size='340' side='right'caption='[[1rfh]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1rfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1rfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RFH FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rfh OCA], [https://pdbe.org/1rfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rfh RCSB], [https://www.ebi.ac.uk/pdbsum/1rfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rfh ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rfh OCA], [https://pdbe.org/1rfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rfh RCSB], [https://www.ebi.ac.uk/pdbsum/1rfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rfh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RASF5_MOUSE RASF5_MOUSE] Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.<ref>PMID:11864565</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Bayer | [[Category: Bayer P]] | ||
[[Category: Guiberman | [[Category: Guiberman E]] | ||
[[Category: Harjes | [[Category: Harjes S]] | ||
[[Category: Herrmann | [[Category: Herrmann C]] | ||
[[Category: Mueller | [[Category: Mueller KH]] | ||
[[Category: Wohlgemuth | [[Category: Wohlgemuth S]] | ||
Latest revision as of 11:22, 1 May 2024
Solution structure of the C1 domain of Nore1, a novel Ras effectorSolution structure of the C1 domain of Nore1, a novel Ras effector
Structural highlights
FunctionRASF5_MOUSE Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References |
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