8fvj: Difference between revisions

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-'''Unreleased structure'''
-The entry 8fvj is ON HOLD
+==Dimeric form of HIV-1 Vif in complex with human CBF-beta, ELOB, ELOC, and CUL5==
+<StructureSection load='8fvj' size='340' side='right'caption='[[8fvj]], [[Resolution|resolution]] 3.54&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8fvj]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FVJ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.54&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fvj OCA], [https://pdbe.org/8fvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fvj RCSB], [https://www.ebi.ac.uk/pdbsum/8fvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fvj ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PEBB_HUMAN PEBB_HUMAN] Note=A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11.
+== Function ==
+[https://www.uniprot.org/uniprot/PEBB_HUMAN PEBB_HUMAN] CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.
-Authors:
+==See Also==
+*[[Virion infectivity factor|Virion infectivity factor]]
-Description:
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Human immunodeficiency virus 1]]
+[[Category: Large Structures]]
+[[Category: Alvarez-Cabrera AL]]
+[[Category: Chen XS]]
+[[Category: Ito F]]
+[[Category: Zhou ZH]]