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==CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH LIGAND== | |||
<StructureSection load='7zpg' size='340' side='right'caption='[[7zpg]], [[Resolution|resolution]] 1.16Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7zpg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZPG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.16Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JQX:[(7R,9aR)-7-(4-chlorophenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-(2-bromanyl-3-methoxy-phenyl)methanone'>JQX</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zpg OCA], [https://pdbe.org/7zpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zpg RCSB], [https://www.ebi.ac.uk/pdbsum/7zpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zpg ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MGLL_HUMAN MGLL_HUMAN] Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.<ref>PMID:20079333</ref> | |||
==See Also== | |||
*[[Lipase 3D Structures|Lipase 3D Structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Grether | [[Category: Large Structures]] | ||
[[Category: | [[Category: Benz J]] | ||
[[Category: | [[Category: Collin L]] | ||
[[Category: Kemble | [[Category: Engelhardt B]] | ||
[[Category: | [[Category: Grether U]] | ||
[[Category: | [[Category: Heer D]] | ||
[[Category: | [[Category: Hornsperger B]] | ||
[[Category: | [[Category: Kemble A]] | ||
[[Category: | [[Category: Kuhn B]] | ||
[[Category: Leibrock L]] | |||
[[Category: Richter H]] | |||
[[Category: Ruf I]] | |||
[[Category: Wittwer M]] | |||
Latest revision as of 10:55, 1 May 2024
CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH LIGANDCRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH LIGAND
Structural highlights
FunctionMGLL_HUMAN Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.[1] See AlsoReferences
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