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<StructureSection load='7op3' size='340' side='right'caption='[[7op3]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='7op3' size='340' side='right'caption='[[7op3]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7op3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OP3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7op3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OP3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7op3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7op3 OCA], [https://pdbe.org/7op3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7op3 RCSB], [https://www.ebi.ac.uk/pdbsum/7op3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7op3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7op3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7op3 OCA], [https://pdbe.org/7op3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7op3 RCSB], [https://www.ebi.ac.uk/pdbsum/7op3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7op3 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/G0S7G9_CHATD G0S7G9_CHATD]
In human cells, P5B-ATPases execute the active export of physiologically important polyamines such as spermine from lysosomes to the cytosol, a function linked to a palette of disorders. Yet, the overall shape of P5B-ATPases and the mechanisms of polyamine recognition, uptake and transport remain elusive. Here we describe a series of cryo-electron microscopy structures of a yeast homolog of human ATP13A2-5, Ypk9, determined at resolutions reaching 3.4 A, and depicting three separate transport cycle intermediates, including spermine-bound conformations. Surprisingly, in the absence of cargo, Ypk9 rests in a phosphorylated conformation auto-inhibited by the N-terminus. Spermine uptake is accomplished through an electronegative cleft lined by transmembrane segments 2, 4 and 6. Despite the dramatically different nature of the transported cargo, these findings pinpoint shared principles of transport and regulation among the evolutionary related P4-, P5A- and P5B-ATPases. The data also provide a framework for analysis of associated maladies, such as Parkinson's disease.


Structure and transport mechanism of P5B-ATPases.,Li P, Wang K, Salustros N, Gronberg C, Gourdon P Nat Commun. 2021 Jun 25;12(1):3973. doi: 10.1038/s41467-021-24148-y. PMID:34172751<ref>PMID:34172751</ref>
==See Also==
 
*[[ATPase 3D structures|ATPase 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7op3" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chatd]]
[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gourdon, P E]]
[[Category: Gourdon PE]]
[[Category: Gronberg, C]]
[[Category: Gronberg C]]
[[Category: Li, P]]
[[Category: Li P]]
[[Category: Salustros, N]]
[[Category: Salustros N]]
[[Category: Wang, K T]]
[[Category: Wang KT]]
[[Category: Spm transporter]]
[[Category: Transport protein]]

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