6erq: Difference between revisions

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New page: '''Unreleased structure''' The entry 6erq is ON HOLD Authors: Hillen, H.S., Morozov, Y.I., Sarfallah, A., Temiakov, D., Cramer, P. Description: Structure of the human mitochondrial tra...
 
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'''Unreleased structure'''


The entry 6erq is ON HOLD
==Structure of the human mitochondrial transcription initiation complex at the HSP promoter==
<StructureSection load='6erq' size='340' side='right'caption='[[6erq]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6erq]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ERQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6erq OCA], [https://pdbe.org/6erq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6erq RCSB], [https://www.ebi.ac.uk/pdbsum/6erq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6erq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TFAM_HUMAN TFAM_HUMAN] Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.<ref>PMID:1737790</ref> <ref>PMID:20410300</ref> <ref>PMID:19304746</ref> <ref>PMID:22037172</ref> <ref>PMID:22037171</ref>


Authors: Hillen, H.S., Morozov, Y.I., Sarfallah, A., Temiakov, D., Cramer, P.
==See Also==
 
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
Description: Structure of the human mitochondrial transcription initiation complex at the HSP promoter
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Temiakov, D]]
__TOC__
[[Category: Morozov, Y.I]]
</StructureSection>
[[Category: Cramer, P]]
[[Category: Homo sapiens]]
[[Category: Hillen, H.S]]
[[Category: Large Structures]]
[[Category: Sarfallah, A]]
[[Category: Cramer P]]
[[Category: Hillen HS]]
[[Category: Morozov YI]]
[[Category: Sarfallah A]]
[[Category: Temiakov D]]

Latest revision as of 10:31, 1 May 2024

Structure of the human mitochondrial transcription initiation complex at the HSP promoterStructure of the human mitochondrial transcription initiation complex at the HSP promoter

Structural highlights

6erq is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 4.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TFAM_HUMAN Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.[1] [2] [3] [4] [5]

See Also

References

  1. ↑ Fisher RP, Lisowsky T, Parisi MA, Clayton DA. DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. J Biol Chem. 1992 Feb 15;267(5):3358-67. PMID:1737790
  2. ↑ Litonin D, Sologub M, Shi Y, Savkina M, Anikin M, Falkenberg M, Gustafsson CM, Temiakov D. Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro. J Biol Chem. 2010 Jun 11;285(24):18129-33. doi: 10.1074/jbc.C110.128918. Epub, 2010 Apr 21. PMID:20410300 doi:http://dx.doi.org/10.1074/jbc.C110.128918
  3. ↑ Gangelhoff TA, Mungalachetty PS, Nix JC, Churchill ME. Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A. Nucleic Acids Res. 2009 Jun;37(10):3153-64. Epub 2009 Mar 20. PMID:19304746 doi:10.1093/nar/gkp157
  4. ↑ Rubio-Cosials A, Sidow JF, Jimenez-Menendez N, Fernandez-Millan P, Montoya J, Jacobs HT, Coll M, Bernado P, Sola M. Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter. Nat Struct Mol Biol. 2011 Oct 30;18(11):1281-9. doi: 10.1038/nsmb.2160. PMID:22037172 doi:10.1038/nsmb.2160
  5. ↑ Ngo HB, Kaiser JT, Chan DC. The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA. Nat Struct Mol Biol. 2011 Oct 30;18(11):1290-6. doi: 10.1038/nsmb.2159. PMID:22037171 doi:10.1038/nsmb.2159

6erq, resolution 4.50Å

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