5k4x: Difference between revisions
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==M. thermoresistible IMPDH in complex with IMP and Compound 1== | |||
<StructureSection load='5k4x' size='340' side='right'caption='[[5k4x]], [[Resolution|resolution]] 1.37Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5k4x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_thermoresistibile Mycolicibacterium thermoresistibile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K4X FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6Q9:~{N}-(2~{H}-INDAZOL-6-YL)-3,5-DIMETHYL-1~{H}-PYRAZOLE-4-SULFONAMIDE'>6Q9</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k4x OCA], [https://pdbe.org/5k4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k4x RCSB], [https://www.ebi.ac.uk/pdbsum/5k4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k4x ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/G7CNL4_MYCT3 G7CNL4_MYCT3] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] | |||
==See Also== | |||
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Blundell | [[Category: Mycolicibacterium thermoresistibile]] | ||
[[Category: | [[Category: Ascher DB]] | ||
[[Category: Blundell TL]] | |||
[[Category: Pacitto A]] | |||
Latest revision as of 10:24, 1 May 2024
M. thermoresistible IMPDH in complex with IMP and Compound 1M. thermoresistible IMPDH in complex with IMP and Compound 1
Structural highlights
FunctionG7CNL4_MYCT3 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] See Also |
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