4d09: Difference between revisions

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-'''Unreleased structure'''
-The entry 4d09 is ON HOLD  until Paper Publication
+==PDE2a catalytic domain in complex with a brain penetrant inhibitor==
+<StructureSection load='4d09' size='340' side='right'caption='[[4d09]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4d09]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D09 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=788:N-BENZYL-4-METHYL-1-PHENYL[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE-8-CARBOXAMIDE'>788</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d09 OCA], [https://pdbe.org/4d09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d09 RCSB], [https://www.ebi.ac.uk/pdbsum/4d09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d09 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref>
-Authors: Buijnsters, P., Andres, J.I., DeAngelis, M., Langlois, X., Rombouts, F., Sanderson, W., Tresadern, G., Trabanco, A., VanHoof, G., VanRoosbroeck, Y.
+==See Also==
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
-Description: PDE2a catalytic domain in complex with a brain penetrant inhibitor
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Andres JI]]
+[[Category: Buijnsters P]]
+[[Category: DeAngelis M]]
+[[Category: Langlois X]]
+[[Category: Rombouts F]]
+[[Category: Sanderson W]]
+[[Category: Trabanco A]]
+[[Category: Tresadern G]]
+[[Category: VanHoof G]]
+[[Category: VanRoosbroeck Y]]