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{{STRUCTURE_4c0k|  PDB=4c0k  |  SCENE=  }}
===Crystal structure of Drosophila Miro EF hand and cGTPase domains bound to one calcium ion (Ca-MiroS)===
{{ABSTRACT_PUBMED_24071720}}


==Function==
==Crystal structure of Drosophila Miro EF hand and cGTPase domains bound to one calcium ion (Ca-MiroS)==
[[http://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME]] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>
<StructureSection load='4c0k' size='340' side='right'caption='[[4c0k]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4c0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C0K FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.801&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0k OCA], [https://pdbe.org/4c0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c0k RCSB], [https://www.ebi.ac.uk/pdbsum/4c0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0k ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>  


==About this Structure==
==See Also==
[[4c0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0K OCA].
*[[Rho GTPase 3D structures|Rho GTPase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:024071720</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Chakravarthy, S.]]
[[Category: Large Structures]]
[[Category: Focia, P J.]]
[[Category: Chakravarthy S]]
[[Category: Freymann, D M.]]
[[Category: Focia PJ]]
[[Category: Klosowiak, J L.]]
[[Category: Freymann DM]]
[[Category: Landahl, E C.]]
[[Category: Klosowiak JL]]
[[Category: Rice, S E.]]
[[Category: Landahl EC]]
[[Category: Wawrzak, Z.]]
[[Category: Rice SE]]
[[Category: Calcium-binding gtpase]]
[[Category: Wawrzak Z]]
[[Category: Hidden ef hand]]
[[Category: Hydrolase]]
[[Category: Kinesin]]
[[Category: Mitochondrial transport]]
[[Category: Mitophagy]]

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